If you're looking for a powerful solution to treat pigmentation, you've probably come across Cosmelan and Dermamelan, two of the most well-known depigmentation treatments by Mesoestetic. But this brings up the big question:
Which one is better for dark spots? And which one is right for you?
In this blog, I’ll break down the differences between Cosmelan and Dermamelan, what they treat, and how to choose the one that suits your skin needs best.
🌞 What Types of Pigmentation Do They Treat?
Both Cosmelan and Dermamelan are designed to treat melanin-based hyperpigmentation, including:
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Melasma
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Sun spots
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Post-inflammatory hyperpigmentation (PIH)
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Uneven skin tone
Their biggest strength? They don’t just fade surface discoloration—they go deeper to regulate the source of excess melanin production.
🔬 What Do They Have in Common?
Both Cosmelan and Dermamelan:
✔️ Are developed by Mesoestetic, a pharmaceutical lab in Spain
✔️ Are 2-phase treatments: an in-clinic mask (phase 1) + at-home maintenance (phase 2 with Cosmelan 2 or Dermamelan Treatment)
✔️ Are safe for all skin types and tones
✔️ Target tyrosinase, the key enzyme in melanin production, while also soothing and protecting the skin
⚖️ What’s the Difference?
| Feature | Cosmelan | Dermamelan |
|---|---|---|
| Depigmenting strength | High | Very high (more intensive formula) |
| Mask wear time | 8–12 hours | 4 hours |
| Peeling/flaking | Mild to moderate (less with new formula) | May cause more visible peeling |
| Best for | Mild to moderate pigmentation | Stubborn melasma or deep discoloration |
| Price | More affordable | Higher (due to stronger ingredients) |
🧴 Which One Should You Choose?
🔹 Choose Cosmelan if...
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It’s your first time treating dark spots
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Your pigmentation is mild or moderate
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You want a powerful treatment with a gentler approach
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You have sensitive or reactive skin
🔹 Choose Dermamelan if...
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You've tried other treatments without success
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You suffer from deep or chronic melasma
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Your pigmentation is severe and resistant
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You're under professional or dermatological supervision
🛡️ What About Aftercare?
Aftercare is essential with both treatments. To maintain results and avoid rebound pigmentation, you’ll need to:
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Apply Cosmelan 2 or Dermamelan Treatment daily for at least 2 months
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Hydrate your skin and use calming products
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Wear broad-spectrum sunscreen every day
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Avoid exfoliating or aggressive treatments during the healing phase
💬 So... Which One Is Better?
There’s no one-size-fits-all answer. It depends on your skin type, pigmentation severity, and goals.
✔️ Cosmelan is a great choice for most people, especially as a first-time or preventative treatment.
✔️ Dermamelan is the stronger version, ideal for advanced cases or stubborn pigmentation.
The best way to choose? Have a professional skin assessment to determine the right plan for your specific condition.
✨ Final Thoughts
Cosmelan and Dermamelan are two of the most trusted depigmentation treatments in the world, and for good reason: they don’t just cover the problem—they treat it at its root.
If you're ready to say goodbye to dark spots with a professional, proven method, either of these treatments can be your skin’s best ally.